The Feucht lab at the University Hospital Tübingen offers exciting research opportunities and a position for a:

PhD student (f/m/d) in CAR T cell therapy

The Feucht Lab (https://www.feucht-leibold-labs.com) aims at improving CAR therapies against cancer and non-malignant diseases. We leverage advanced technologies including CRISPR/Cas9 genome engineering, live cell imaging and cutting-edge omics to gain improved understanding into CAR biology and underlying mechanisms of responses and therapeutic failures. We apply clinically relevant models to develop enhanced therapies with the overall goal to translate our insights into improved patient care.

The Feucht lab is supported by the iFIT Cluster of Excellence (EXC2180) and an ERC Starting grant, providing excellent opportunities for training, mentoring and career development.

Key publications:

Jain N*, Zhao Z*, Feucht J et al. TET2 guards against unchecked BATF3-induced CAR T cell expansion. Nature 2023. Link

Amor C*, Feucht J*, Leibold J* et al. Senolytic CAR T cells reverse senescence-associated pathologies. Nature 2020. Link

Feucht J*, Sun J* et al. Calibration of CAR activation potential directs alternative T cell fates and therapeutic potency.Nat Med 2019. Link

Your key responsibilities:

• Design, plan and conduct research experiments
• Establish novel assays and models
• Analysis, interpretation and presentation of research findings
• Contribute to grant writing, research reports and publications
• Scientific literature research and development of new ideas

Your profile:

• Motivation, passion and excitement for science
• Diploma or Master’s Degree (or equivalent) in biology, biochemistry, life sciences or related disciplines
• Practical experience in cell culture techniques, immunological assays and/or molecular biology
• Proficiency (oral and written) in English
• Creativity and thinking outside the box are encouraged
• Enthusiastic learning and collaborative working attitude
• Practical skills in animal experimentation (FELASA B or comparable) and/ or computational skills are a plus

Benefits for you:

• An interesting and diverse job with an exciting high-profile research project in a highly

innovative and impactful research field

• A dynamic and versatile workplace with a supportive and collaborative atmosphere, a highly motivated team and modern equipment
• Excellent training opportunities and close collaborations with partners in and outside of Tübingen  
• Attend scientific conferences to build networks and present your research
• Living in one oft the most enjoyable and ecological towns with a long history in academic excellence (BBC & ZEIT).

About Eberhard Karls Universität Tübingen

The Eberhard Karls Universität Tübingen is an international and interdisciplinary research institution and has been awarded the status of a University of Excellence. Tübingen houses three internationally recognized research clusters in cancer immunology (iFIT), machine learning and AI (ML), and infection medicine (CMFI). The University Hospital has a strong track record in translational research and houses innovative clinical centers (Comprehensive Cancer Center, German Cancer Consortium, National Center for Tumor Diseases).

How to apply:

The start date for the position is July 2025. Severely handicapped persons with equal qualifications are given preferential consideration. The University of Tübingen is committed to increase the percentage of female scientists and therefore encourages women to apply for this position. Salary is paid according to TV-L (65% E13).

Please send your application forms including a cover letter, your CV as well as contact details for two references via e-mail (single pdf) or in written form to:

Judith Feucht, M.D.

W2 Professor for Cellular Immunotherapies in Cancer

Cluster of Excellence iFIT (EXC2180)

Röntgenweg 11

72076 Tübingen, Germany

Email: judith.feucht@med.uni-tuebingen.de