The Cluster of Excellence (EXC2180) “Image-Guided and Functionally Instructed Tumor

Therapies (iFIT)” is a multidisciplinary and interdisciplinary research program that focuses on

understanding tumor biology and the development of novel diagnostic and therapeutic

approaches for cancer.

The iFIT research group of Jun. Prof. Dr. Josef Leibold is looking for a

Postdoc (f/m/d) in Functional Immunogenomics.

The Leibold Lab (https://www.feucht-leibold-labs.com), supported by an ERC Starting Grant

and the iFIT Excellence Cluster, develops innovative therapeutic approaches for solid tumors.

These include chimeric antigen receptor (CAR) T and NK cells combined with targeted

therapies and immune-modulatory agents. By leveraging advanced technologies like

CRISPR/Cas9 genome engineering and cutting-edge mouse models, the lab aims to restore

immunosurveillance mechanisms and enhance immunotherapeutic strategies for late-stage

and metastatic cancers.

Key publications:

Leibold J*, Tsanov K*, Amor C* et al. Somatic mouse models of gastric cancer reveal genotype-specific features of metastatic disease.Nature Cancer 2024. Link

Paffenholz et al. Senescence induction dictates response to chemo- and immunotherapy in preclinical models of ovarian cancer.PNAS 2022. Link

Amor C*, Feucht J*, Leibold J* et al. Senolytic CAR T cells reverse senescence-associated pathologies. Nature 2020. Link

Leibold J*, Ruscetti M*, Cao Z* et al. Somatic tissue engineering in mouse models reveals an actionable role for WNT pathway alterations in prostate cancer metastasis.Cancer Discov 2020. Link

Your key responsibilities:

• Design, conduct and analyze research experiments
• Establish novel assays and models
• Interpret data, write manuscripts, and present findings at conferences and seminars
• Collaborate with internal and external partners (national and international)
• Supervise master candidates and PhD students

Your profile:

• A doctoral degree in Molecular Biology, Biochemistry or a related disciplines
• Practical experience in cell culture techniques and in the application of a range of

molecular biology methods

• Passion for cancer research, immunology and biomedical research
• Creativity and thinking outside the box are encouraged
• Enthusiastic learning and collaborative working attitude
• Excellent written and oral communication skills in English
• Practical skills in animal experimentation (FELASA B or comparable) and/ or computational skills are a plus

Benefits for you:

• An interesting and diverse job with an exciting high-profile research project in a highly

innovative and impactful research field

• A dynamic and versatile workplace with a supportive and collaborative atmosphere, a highly motivated team and modern equipment
• Develop an independent track record as part of your career growth
• Attend scientific conferences to build networks and present your research
• Fully funded postdoc position (remuneration according to TV-L salary scale 13)
• Living in one oft the most enjoyable and ecological towns with a long history in academic excellence (BBC & ZEIT).

About Eberhard Karls Universität Tübingen

The Eberhard Karls Universität Tübingen is an international and interdisciplinary research institution and has been awarded the status of a University of Excellence. Tübingen houses three internationally recognized research clusters in cancer immunology (iFIT), machine learning and AI (ML), and infection medicine (CMFI). The University Hospital has a strong track record in translational research and houses innovative clinical centers (Comprehensive Cancer Center, German Cancer Consortium, National Center for Tumor Diseases).

How to apply:

The earliest possible start date is May 2025 and the position is offered for 2 years with

plans for further extension. Severely handicapped persons with equal qualifications are given preferential consideration. The University of Tübingen is committed to increase the percentage of female scientists, and therefore encourages women to apply for this position. The Administration of the University Hospital is responsible for all employment matters.

Please send your application forms including a cover letter, your CV as well as contact details for two references via e-mail (single pdf) or in written form to:

Josef Leibold, M.D.

Juniorprofessor for Functional Immunogenomics

Cluster of Excellence iFIT (EXC2180)

Röntgenweg 11

72076 Tübingen, Germany

Email: Josef.Leibold@med.uni-tuebingen.de