The project proposed aims to support the structuring and defining of a more precise and specific assessment model to be implemented in the evaluation of the digital ecosystems. In addition, the project also aims to study computational models for evaluating and improving the efficiency of healthcare processes and pathways, to support decision-making at managerial and clinical level. It is essential, especially due to the extensive digital technologies and artificial intelligence use, to define methodological approaches that could optimize the decision-making process, providing support and efficiency, on the basis of specific needs, in line with the new requirements of the European Regulation and concerning social, economic and environmental sustainability measures.