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Development of Novel Therapeutic Approaches for Esophageal Carcinoma

ResearchJobs.cz
18 Oct 2023

Job Information

Organisation/Company
Masaryk University, Faculty of Medicine
Research Field
Medical sciences » Medicine
Researcher Profile
First Stage Researcher (R1)
Country
Czech Republic
Application Deadline
Type of Contract
Other
Job Status
Other
Offer Starting Date
Is the job funded through the EU Research Framework Programme?
Not funded by an EU programme
Is the Job related to staff position within a Research Infrastructure?
No

Offer Description

Specialization: Biochemistry and Molecular Biology
Workplace: Masaryk Memorial Cancer Institute
RECAMO
Žlutý kopec 7, Brno 65653

Supervisor: Doc. MUDr. Radka Lordick Obermannová, Ph.D. (obermannova@mou.cz)
Lab´s website:https://www.mou.cz/en/recamo/t1630

Title: Development of Novel Therapeutic Approaches for Esophageal Carcinoma

 

Brief annotation:

Esophageal carcinoma is a global health challenge marked by high morbidity and mortality rates. Despite treatment advancements, therapy resistance remains a significant hurdle, driven by intricate signaling pathways governing tumor growth, metastasis, and treatment responses. The offered research project focuses on these pathways using cutting-edge proteomic techniques. Our primary objective is to pinpoint pivotal signaling pathways in esophageal cancer’s progression and therapy resistance. Advanced phosphoproteomics analysis will systematically profile and map phosphorylation events within these pathways, shedding light on abnormal activation and potential therapeutic targets. We will experimentally evaluate inhibitors and antibodies targeting these pathways, uncovering their impact on tumor growth, metastasis, and therapy resistance. This comprehensive understanding may also identify potential therapy response biomarkers. In summary, our research addresses esophageal carcinoma’s therapy resistance through a deep dive into signaling networks, offering potential breakthroughs for more effective treatments in a concise and focused manner.

Funding: EU project PRESSURE

https://pressurenetwork.eu/jobs/#

https://euraxess.ec.europa.eu/jobs/152335

Requirements:

Note that the MSCA-ITN mobility clause applies; the applicant may not have spent 12 months or more in the past 3 years in the country where the position is offered. Candidates may not already hold a doctoral degree. Candidate must be eligible to work according to your host country’s regulations (for instance visa requirements), and to work in other European countries for secondments and meetings.

Please submit your application until November 1st. Note that your application may be forwarded to other Beneficiaries in the consortium.

Please include the following documents:

  • Letter of motivation/research statement (1-2 pages). This should include a description of past work, but also a vision on how you see yourself fit in the consortium and the position you are applying for.
  • Curriculum vitae (CV)
  • Contact information for 2-3 references

 

Requirements

Additional Information

Work Location(s)

Number of offers available
1
Company/Institute
Masaryk University, Faculty of Medicine
Country
Czech Republic

Where to apply

E-mail
petr.bures@med.muni.cz