PhD position in Molecular Immunology

The research group Prof Dr. Dirk Schlüter, Director of the Institute for Medical Microbiology and Hospital Epidemiology at Hannover Medical School (Germany) offers a PhD position in

                                      Molecular function of deubiqutinating enzymes in intestinal bacterial infection

starting from July, 2021.

The project investigates how deubiquitinating enzymes regulate the outcome of intestinal bacterial infections. This project involves the use of mouse model of infectious disease together with human/murine intestinal organoids with specific deletion of signal transducing molecules. The combined in vivo and in vitro experiments include immunological (cell proliferation assays, cytotoxicity assays, FACS, MACS, cell culture, CBA, ELISA), molecular biological (qPCR, siRNA, CRISPR-Cas9–mediated gene knockout) and biochemical (WB, IP) techniques.

The salary and benefits are according to 65% of the TV-L guidelines with additional budget for material expenses and financial support for attending conferences.

We are seeking a highly motivated PhD candidate with a good university degree in biology, immunology, molecular biology, biochemistry, medicine or veterinary medicine and keen interest in immunology of infectious diseases. Good written and spoken English skills are mandatory.

Recent publications from the group

Koschel J, Nishanth G, Just S, Harit K, Kröger A, Deckert M, Naumann M, Schlüter D (2021) OTUB1 prevents lethal hepatocyte necroptosis through stabilization of c-IAP1 during murine liver inflammation. Cell Death Diff. DOI: 10.1038/s41418-021-00752-9.

Mulas F, Wang X, Song S, Nishanth G, Yi W, Brunn A, Larsen PK, Isermann B, Kalinke U, Barragan A, Naumann M, Deckert M, Schlüter D (2020) The deubiquitinase OTUB1 augments NF-kB dependent immune responses of dendritic cells by stabilization of UBC13 in infection and inflammation. Cell Mol Immunol. DOI: 10.1038/s41423-020-0362-6.

Wang X, Mulas F, Yi W, Brunn A, Nishanth G, Just S, Waisman A, Brück W, Deckert M, Schlüter D (2019) The deubiquitinase OTUB1 inhibits central nervous system autoimmunity by preventing IFN-γ-induced hyperactivation of astrocytes through stabilization of SOCS1. EMBO J 38(10): e100947. DOI: 10.15252/embj.2018100947.

Please, send applications including CV, score sheets, interests of research and references to:

Prof Dr. Dirk Schlüter

Institute for Medical Microbiology and Hospital Epidemiology

Hannover Medical School

Carl-Neuberg-Str. 1

Building J6

30625 Hannover

e-mail:Schlueter.Dirk@mh-hannover.de