Call for expressions of interest for the submission of Marie Sklodowska Curie proposals in Cell Cycle Control

Our group is ultimately interested in deciphering the mechanisms that control cell cycle

progression and, specifically, the regulatory events controlling the G1-to-S transition of

the cell cycle in mitosis and meiosis. The candidate will characterize the regulation of

the yeast MBF complex, which is the functional homolog of human RB-E2F, through

alternative CDKs. The exact knowledge of how the MBF complex is activated or

repressed will help to understand not only the regulation of the G1-to-S transition in

fission yeast, but also will help to improve our knowledge and understanding of the

“restriction point” in mammalian cells. We plan to tackle this project from different

approximations, including the use of some genetically-encoded fluorescent reporters to

measure cell cycle progression that have developed in our lab.

As a consequence of developing a multidisciplinary project, a solid background in

Genetics, Cell Biology and Molecular Biology is a requirement to carry out this project;

previous work with yeast and/or cell cycle is not required, but will be a plus. Our group

and the Department will also be involved in the candidate’s career development.